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Title: | Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan | Authors: | BELMANS, Niels Gilles, Liese Vermeesen, Randy Virag, Piroska Hedesiu, Mihaela Salmon, Benjamin Baatout, Sarah Lucas, Stephane LAMBRICHTS, Ivo Jacobs, Reinhilde MOREELS, Marjan |
Issue Date: | 2020 | Publisher: | NATURE PUBLISHING GROUP | Source: | SCIENTIFIC REPORTS, 10 (1) (Art N° 2113) | Abstract: | Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines. | Notes: | Moreels, M (corresponding author), SCK CEN, Belgian Nucl Res Ctr, Radiobiol Unit, Mol, Belgium. marjan.moreels@sckcen.be |
Other: | Moreels, M (corresponding author), SCK CEN, Belgian Nucl Res Ctr, Radiobiol Unit, Mol, Belgium. marjan.moreels@sckcen.be | Keywords: | Buccal Mucosa Cells;Cone-Beam Ct;Gamma-H2ax Foci;Cancer-Risk;Computed-Tomography;Ionizing-Radiation;Adaptive Response;Subsequent Risk;Nucleotide Pool;Brain-Tumor | Document URI: | http://hdl.handle.net/1942/32803 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-58746-5 | ISI #: | WOS:000562828900010 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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s41598-020-58746-5.pdf | Published version | 1.72 MB | Adobe PDF | View/Open |
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