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Title: | Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic: Perspective from a European country | Authors: | MOLENBERGHS, Geert BUYSE, Marc ABRAMS, Steven HENS, Niel Beutels, Philippe FAES, Christel VERBEKE, Geert Van Damme, Pierre Goossens, Herman NEYENS, Thomas HERZOG, Sereina Theeten, Heidi Pepermans, Koen Abad, Ariel Alonso VAN KEILEGOM, Ingrid Speybroeck, Niko LEGRAND, Catherine De Buyser, Stefanie Hulstaert, Frank |
Issue Date: | 2020 | Publisher: | ELSEVIER SCIENCE INC | Source: | Contemporary Clinical Trials, 99 (Art N° 106189) | Abstract: | Starting from historic reflections, the current SARS-CoV-2 induced COVID-19 pandemic is examined from various perspectives, in terms of what it implies for the implementation of non-pharmaceutical interventions, the modeling and monitoring of the epidemic, the development of early-warning systems, the study of mortality, prevalence estimation, diagnostic and serological testing, vaccine development, and ultimately clinical trials. Emphasis is placed on how the pandemic had led to unprecedented speed in methodological and clinical development, the pitfalls thereof, but also the opportunities that it engenders for national and international collaboration, and how it has simplified and sped up procedures. We also study the impact of the pandemic on clinical trials in other indications. We note that it has placed biostatistics, epidemiology, virology, infectiology, and vaccinology, and related fields in the spotlight in an unprecedented way, implying great opportunities, but also the need to communicate effectively, often amidst controversy. | Notes: | Buyse, M (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Data Sci Inst, Martelarenlaan 42, Hasselt, Belgium. marc.buyse@iddi.com |
Other: | Buyse, M (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Data Sci Inst, Martelarenlaan 42, Hasselt, Belgium. marc.buyse@iddi.com | Keywords: | SARS-CoV-2;Antiviral therapy;Diagnostic testing;Infection fatality rate;Mortality;Non-pharmaceutical intervention;Nowcasting;Prevalence;Mathematical epidemiology;Mathematical modeling;Vaccine development;Pragmatic trials;Factorial designs;Platform trials;Data sharing | Document URI: | http://hdl.handle.net/1942/33155 | ISSN: | 1551-7144 | e-ISSN: | 1559-2030 | DOI: | 10.1016/j.cct.2020.106189 | ISI #: | WOS:000599523300015 | Rights: | © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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1-s2.0-S1551714420302676-main.pdf | Published version | 1.09 MB | Adobe PDF | View/Open |
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