Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/33155
Title: Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic: Perspective from a European country
Authors: MOLENBERGHS, Geert 
BUYSE, Marc 
ABRAMS, Steven 
HENS, Niel 
Beutels, Philippe
FAES, Christel 
VERBEKE, Geert 
Van Damme, Pierre
Goossens, Herman
NEYENS, Thomas 
HERZOG, Sereina 
Theeten, Heidi
Pepermans, Koen
Abad, Ariel Alonso
VAN KEILEGOM, Ingrid 
Speybroeck, Niko
LEGRAND, Catherine 
De Buyser, Stefanie
Hulstaert, Frank
Issue Date: 2020
Publisher: ELSEVIER SCIENCE INC
Source: Contemporary Clinical Trials, 99 (Art N° 106189)
Abstract: Starting from historic reflections, the current SARS-CoV-2 induced COVID-19 pandemic is examined from various perspectives, in terms of what it implies for the implementation of non-pharmaceutical interventions, the modeling and monitoring of the epidemic, the development of early-warning systems, the study of mortality, prevalence estimation, diagnostic and serological testing, vaccine development, and ultimately clinical trials. Emphasis is placed on how the pandemic had led to unprecedented speed in methodological and clinical development, the pitfalls thereof, but also the opportunities that it engenders for national and international collaboration, and how it has simplified and sped up procedures. We also study the impact of the pandemic on clinical trials in other indications. We note that it has placed biostatistics, epidemiology, virology, infectiology, and vaccinology, and related fields in the spotlight in an unprecedented way, implying great opportunities, but also the need to communicate effectively, often amidst controversy.
Notes: Buyse, M (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Data Sci Inst, Martelarenlaan 42, Hasselt, Belgium.
marc.buyse@iddi.com
Other: Buyse, M (corresponding author), Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Data Sci Inst, Martelarenlaan 42, Hasselt, Belgium. marc.buyse@iddi.com
Keywords: SARS-CoV-2;Antiviral therapy;Diagnostic testing;Infection fatality rate;Mortality;Non-pharmaceutical intervention;Nowcasting;Prevalence;Mathematical epidemiology;Mathematical modeling;Vaccine development;Pragmatic trials;Factorial designs;Platform trials;Data sharing
Document URI: http://hdl.handle.net/1942/33155
ISSN: 1551-7144
e-ISSN: 1559-2030
DOI: 10.1016/j.cct.2020.106189
ISI #: WOS:000599523300015
Rights: © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Category: A1
Type: Journal Contribution
Validations: ecoom 2022
Appears in Collections:Research publications

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