Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/33739
Title: | SPECS : a non-parameteric method to identify tissue-specific molecular features for unbalanced sample groups | Authors: | Everaert, Celine Volders, Pieter-Jan Morlion, Annelien THAS, Olivier Mestdagh, Pieter |
Issue Date: | 2019 | Publisher: | Cold Spring Harbor Laboratory | Abstract: | To understand biology and differences among various tissues or cell types, one typically searches for molecular features that display characteristic abundance patterns. Several specificity metrics have been introduced to identify tissue-specific molecular features, but these either require an equal number of replicates per tissue or they can't handle replicates at all. We describe a non-parametric specificity score that is compatible with unequal sample group sizes. To demonstrate its usefulness, the specificity score was calculated on all GTEx samples, detecting known and novel tissue-specific genes. A webtool was developed | Document URI: | http://hdl.handle.net/1942/33739 | DOI: | 10.1101/656397 | Category: | O | Type: | Preprint |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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656397v1.full.pdf | Non Peer-reviewed author version | 671.22 kB | Adobe PDF | View/Open |
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