Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/33984
Title: Diagnostic scores predict morbidity and mortality in patients hospitalized for heart failure with preserved ejection fraction
Authors: VERBRUGGE, Frederik 
Reddy, Yogesh N., V
Sorimachi, Hidemi
Omote, Kazunori
Carter, Rickey E.
Borlaug, Barry A.
Issue Date: 2021
Publisher: WILEY
Source: EUROPEAN JOURNAL OF HEART FAILURE, 23(6), p. 954-963
Abstract: Aims To investigate the prognostic value of diagnostic scores for heart failure (HF) with preserved ejection fraction (HFpEF). Methods and results Consecutive patients with HFpEF admitted for unequivocal decompensated HF treated with intravenous loop diuretics were evaluated (n = 443; mean age 78 +/- 12 years; 60% women). The HFA-PEFF and H2FPEF scores were calculated for all patients with echocardiography data available within 1 year and the population was stratified according to HFA-PEFF scores 2-4 (n = 79), 5 (n = 93), or 6 (n = 271) and H2FPEF score probabilities <90% (n = 80), 90-95% (n = 61), and 96-100% (n = 293). HF readmission rates (95% confidence intervals) increased from 28.9 (22.7-35.0) per 100 patient-years in HFA-PEFF 2-4 to 46.0 (38.5-53.5) in HFA-PEFF 5 and 45.0 (40.1-49.8) in HFA-PEFF 6. Similarly, HF readmission rates increased with increasing H2FPEF probability: <0.90 [31.8 (25.3-38.2) per 100 patient-years], 0.90-0.95 [41.5 (32.9-50.1)], and 0.96-1.00 [45.9 (41.2-50.6]. Median survival was 65 months (36-89 months) in HFA-PEFF score 2-4, 45 months (26-59 months) in HFA-PEFF score 5, and 28 months (22-42 months) in HFA-PEFF score 6 (P < 0.001), while the hazard ratio (95% confidence interval) for all-cause mortality was 1.16 (1.02-1.32) per 0.10 increase in H2FPEF probability. Conclusions Among patients hospitalized with HFpEF, higher HFpEF probability according to diagnostic scores is associated with increased risk of subsequent HF readmissions and all-cause mortality.
Notes: Borlaug, BA (corresponding author), Mayo Clink & Fdn, 200 First St SW, Rochester, MN 55905 USA.
borlaug.barry@mayo.edu
Other: Borlaug, BA (corresponding author), Mayo Clink & Fdn, 200 First St SW, Rochester, MN 55905 USA. borlaug.barry@mayo.edu
Keywords: Cause of death;Diastolic heart failure;Mortality;Patient readmission;Risk assessment
Document URI: http://hdl.handle.net/1942/33984
ISSN: 1388-9842
e-ISSN: 1879-0844
DOI: 10.1002/ejhf.2142
ISI #: WOS:000626761200001
Category: A1
Type: Journal Contribution
Validations: ecoom 2022
Appears in Collections:Research publications

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