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http://hdl.handle.net/1942/343
Title: | Pseudolikelihood modelling of multivariate outcomes in developmental toxicology | Authors: | GEYS, Helena MOLENBERGHS, Geert Ryan, Louise M. |
Issue Date: | 1999 | Publisher: | AMER STATISTICAL ASSOC | Source: | Journal of the American Statistical Association, 94(447). p. 734-745 | Abstract: | The primary goal of this article is to determine benchmark doses based on the ethylene glycol study, which comprises data from a developmental toxicity study in mice. Because the data involve a vector of malformation indicators, a flexible model for multivariate clustered data is required. An exponential family model is considered and pseudolikelihood-based inferential tools are proposed, hence avoiding excessive computational requirements. | Document URI: | http://hdl.handle.net/1942/343 | DOI: | 10.1080/01621459.1999.10474176 | ISI #: | 000082756400014 | Type: | Journal Contribution | Validations: | ecoom 2000 |
Appears in Collections: | Research publications |
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