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http://hdl.handle.net/1942/345
Title: | A note on the comparison of pseudo-likelihood and generalized estimating equations for marginally specified odds ratio models | Authors: | GEYS, Helena MOLENBERGHS, Geert Lipsitz, Stuart R. |
Issue Date: | 1998 | Source: | Journal of Statistical Computation and Simulation, 62(1-2). p. 45-72 | Abstract: | In the framework of a marginally specified odds ratio model for multivariate, clustered binary data, full maximum likelihood estimation can become prohibitive, especially with large within-unit replication. We describe two alternative estimation procedures, pseduo-likelihood and generalized estimating equations, which are easier to fit. The second one is generally well known. Their relative merits are discussed and illustrated using data from developmental toxicity studies. Our attention in this paper is limited to exchangeable association structures. The extension to longitudinal data, which typically call for more complicated association designs, need further investigation. A limited simulation study is performed. | Keywords: | clustered binary data; Dale model, marginal odds ratio; maximum likelihood | Document URI: | http://hdl.handle.net/1942/345 | ISSN: | 0094-9655 | e-ISSN: | 1563-5163 | DOI: | 10.1080/00949659808811924 | ISI #: | 000078529700004 | Rights: | (c) 1998 OPA (Overseas Publishers Association) N.V. | Type: | Journal Contribution | Validations: | ecoom 2000 |
Appears in Collections: | Research publications |
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geys1998.pdf Restricted Access | Published version | 1.95 MB | Adobe PDF | View/Open Request a copy |
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