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http://hdl.handle.net/1942/3496
Title: | Polymers for colon specific drug delivery | Authors: | Schacht, E Gevaert, A Kenawy, ER Molly, K Verstraete, W ADRIAENSENS, Peter CARLEER, Robert GELAN, Jan |
Issue Date: | 1996 | Publisher: | ELSEVIER SCIENCE BV | Source: | JOURNAL OF CONTROLLED RELEASE, 39(2-3). p. 327-338 | Abstract: | Azo-linked polymeric prodrugs of 5-aminosalicylic acid (5-ASA) were prepared and evaluated in simulated human intestinal microbial ecosystem. Release of 5-ASA was demonstrated. Polyamides containing azo groups in the backbone were prepared and tested in vitro in a reductive buffer or in the bioreactor medium. It was demonstrated that for the hydrophobic polymer reduction stops at the hydrazine stage whereas for a hydrophilic analogue reduction with formation of amines occurred. | Notes: | MICROBIAL ECOL LAB,B-9000 GHENT,BELGIUM. UNIV LIMBURG,MAT RES INST,B-3590 DIEPENBEEK,BELGIUM.Schacht, E, STATE UNIV GHENT,BIOMAT & POLYMER RES GRP,KRIJGSLAAN 281,B-9000 GHENT,BELGIUM. | Keywords: | 5-aminosalicylic acid; azo polymer; prodrug colon targeting; coating; degradation; human colon | Document URI: | http://hdl.handle.net/1942/3496 | DOI: | 10.1016/0168-3659(95)00184-0 | ISI #: | A1996UT43200022 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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