Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3496
Title: Polymers for colon specific drug delivery
Authors: Schacht, E
Gevaert, A
Kenawy, ER
Molly, K
Verstraete, W
ADRIAENSENS, Peter 
CARLEER, Robert 
GELAN, Jan 
Issue Date: 1996
Publisher: ELSEVIER SCIENCE BV
Source: JOURNAL OF CONTROLLED RELEASE, 39(2-3). p. 327-338
Abstract: Azo-linked polymeric prodrugs of 5-aminosalicylic acid (5-ASA) were prepared and evaluated in simulated human intestinal microbial ecosystem. Release of 5-ASA was demonstrated. Polyamides containing azo groups in the backbone were prepared and tested in vitro in a reductive buffer or in the bioreactor medium. It was demonstrated that for the hydrophobic polymer reduction stops at the hydrazine stage whereas for a hydrophilic analogue reduction with formation of amines occurred.
Notes: MICROBIAL ECOL LAB,B-9000 GHENT,BELGIUM. UNIV LIMBURG,MAT RES INST,B-3590 DIEPENBEEK,BELGIUM.Schacht, E, STATE UNIV GHENT,BIOMAT & POLYMER RES GRP,KRIJGSLAAN 281,B-9000 GHENT,BELGIUM.
Keywords: 5-aminosalicylic acid; azo polymer; prodrug colon targeting; coating; degradation; human colon
Document URI: http://hdl.handle.net/1942/3496
DOI: 10.1016/0168-3659(95)00184-0
ISI #: A1996UT43200022
Type: Journal Contribution
Appears in Collections:Research publications

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