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http://hdl.handle.net/1942/35723
Title: | Vascular health assessment with flow-mediated dilatation and retinal image analysis: a pilot study in an adult population from Cape Town | Authors: | Marincowitz, Clara Webster, Ingrid Westcott, Corli Goswami, Nandu DE BOEVER, Patrick Seidel, Gerald Strijdom, Hans |
Issue Date: | 2021 | Publisher: | CLINICS CARDIVE PUBL PTY LTD | Source: | CARDIOVASCULAR JOURNAL OF AFRICA, 32 (3) , p. 133 -140 | Abstract: | Aim: Flow-mediated dilatation (FMD) and retinal vascular analysis (RVA) may assist in predicting cardiovascular disease (CVD) but are poorly characterised in South Africa. We recorded baseline FMD and retinal vascular widths in healthy participants, and investigated associations with cardiovascular risk factors. Methods: Endothelial function (measured with FMD), microvascular structure (evaluated via fundus image analysis) and major CVD risk factors were assessed in 66 participants from Cape Town. Results: Median FMD% was 9.6%, with higher values in females. Mean retinal arteriolar and venular widths were similar to 156 and similar to 250 mu m, respectively. FMD was not associated with CVD risk factors. Hypertension was associated with narrower retinal arterioles and venules. Conclusions: We report novel baseline FMD data in healthy South African adults from the Western Cape, and show that retinal microvascular calibres are associated with blood pressure. Our baseline FMD and RVA data could serve as a reference for future studies in South Africa. | Notes: | Webster, I (corresponding author), Stellenbosch Univ, Ctr Cardiometab Res Africa, Div Med Physiol, Cape Town, South Africa. iwebster@sun.ac.za |
Keywords: | vascular health;endothelial function;flow-mediated dilatation;retinal imaging;cardiovascular risk | Document URI: | http://hdl.handle.net/1942/35723 | ISSN: | 1995-1892 | e-ISSN: | 1680-0745 | DOI: | 10.5830/CVJA-2020-046 | ISI #: | WOS:000672606600005 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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180569.pdf | Published version | 105.24 kB | Adobe PDF | View/Open |
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