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Title: | Infections at the nexus of metabolic-associated fatty liver disease | Authors: | Boeckmans, J Rombaut, M Demuyser, T Declerck , B Pierard, D Rogiers, V De Kock, J WAUMANS, Luc MAGERMAN, Koen Cartuyvels , R RUMMENS, Jean-Luc Rodrigues, RM Vanhaecke, T |
Issue Date: | 2021 | Publisher: | SPRINGER HEIDELBERG | Source: | Archives of toxicology, 95 (7) , p. 2235 -2253 | Abstract: | Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease that affects about a quarter of the world population. MAFLD encompasses different disease stadia ranging from isolated liver steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma. Although MAFLD is considered as the hepatic manifestation of the metabolic syndrome, multiple concomitant disease-potentiating factors can accelerate disease progression. Among these risk factors are diet, lifestyle, genetic traits, intake of steatogenic drugs, male gender and particular infections. Although infections often outweigh the development of fatty liver disease, pre-existing MAFLD could be triggered to progress towards more severe disease stadia. These combined disease cases might be underreported because of the high prevalence of both MAFLD and infectious diseases that can promote or exacerbate fatty liver disease development. In this review, we portray the molecular and cellular mechanisms by which the most relevant viral, bacterial and parasitic infections influence the progression of fatty liver disease and steatohepatitis. We focus in particular on how infectious diseases, including coronavirus disease-19, hepatitis C, acquired immunodeficiency syndrome, peptic ulcer and periodontitis, exacerbate MAFLD. We specifically underscore the synergistic effects of these infections with other MAFLD-promoting factors. | Keywords: | Metabolic-associated fatty liver disease (MAFLD);Non-alcoholic steatohepatitis (NASH);Infectious diseases;Lipid metabolism;Liver;SARS-CoV-2;Human immunodeficiency virus;Hepatitis C;Helicobacter pylori;Klebsiella pneumoniae | Document URI: | http://hdl.handle.net/1942/36196 | ISSN: | 0340-5761 | e-ISSN: | 1432-0738 | DOI: | 10.1007/s00204-021-03069-1 | ISI #: | 000653175400002 | Rights: | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2022 |
Appears in Collections: | Research publications |
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Infections at the nexus of metabolic-associated fatty liver disease.pdf | Published version | 1.74 MB | Adobe PDF | View/Open |
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