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http://hdl.handle.net/1942/371
Title: | Flexible quantitative risk assessment for developmental toxicity based on fractional polynomial predictors | Authors: | GEYS, Helena MOLENBERGHS, Geert DECLERCK, Lieven Ryan, Louise |
Issue Date: | 2000 | Publisher: | AKADEMIE VERLAG | Source: | Biometrical Journal, 42(3). p. 279-302 | Abstract: | Risk assessment for developmental toxicity studies in rodents is faced with the fairly involved data structure of clustered multivariate binary outcomes. While likelihood methods for this setting do not abound, we show that a conditional model, combined with pseudo-likelihood inference and fractional polynomial predictor functions, as proposed by Royston and Altman (1994), are a promising way forward. The methods are illustrated using teratology data collected under the National Toxicology Program. | Keywords: | benchmark dose; clustering; conditional model; dose-response model; effective dose | Document URI: | http://hdl.handle.net/1942/371 | ISSN: | 0323-3847 | e-ISSN: | 1521-4036 | DOI: | 10.1002/1521-4036(200007)42:3<279::AID-BIMJ279>3.0.CO;2-F | ISI #: | 000087923500002 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2001 |
Appears in Collections: | Research publications |
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