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Title: | Causative agents of bloodstream infections in two Croatian hospitals and their resistance mechanisms | Authors: | Bedenic, Branka Likic, Sasa Zizek, Marta Bratic, Vesna D'ONOFRIO, Valentino Cavric, Gordana Pavlisa, Gordana Vodanovic, Marijo GYSSENS, Inge Barisic, Ivan |
Issue Date: | 2022 | Publisher: | TAYLOR & FRANCIS LTD | Source: | JOURNAL OF CHEMOTHERAPY, 35 (4) , p. 281-291 | Abstract: | Blood samples were collected alongside with routine blood cultures (BC) from patients with suspected sepsis, to evaluate the prevalence of different causative agents in patients with bacteraemia. Among 667 blood samples, there were 122 positive BC (18%). Haemoglobin content, platelet number, and systolic blood pressure values were significantly lower in patients with positive BC, whereas serum lactate levels, CRP, creatinine and urea content were significantly higher in patients with positive BC. The rate of multidrug (MDR) or extensively drug resistant (XDR) bacteria was 24% (n = 29): Klebsiella pneumoniae (9), Pseudomonas aeruginosa (9), Acinetobacter baumannii (4), Escherichia coli (1), vancomycin resistant Enterococcus spp (VRE) (3), and methicillin-resistant Staphylococcus aureus MRSA (3). The dominant resistance mechanisms were the production of extended-spectrum beta-lactamases, OXA-48 carbapenemase, and colistin resistance in K. pneumoniae, VIM metallo-beta-lactamases in P. aeruginosa and OXA-23-like oxacillinases in A. baumannii. The study revealed high rate of MDR strains among positive BCs in Zagreb, Croatia. | Notes: | Bedenic, B (corresponding author), Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Clin Dept Clin & Mol Microbiol, Zagreb, Croatia. branka.bedenic@kbc-zagreb.hr |
Keywords: | Multidrug-resistant bacteria;Klebsiella pneumonia;eAcinetobacter baumannii;bloodstream infections;extended-spectrum beta-lactamases | Document URI: | http://hdl.handle.net/1942/38128 | ISSN: | 1120-009X | e-ISSN: | 1973-9478 | DOI: | 10.1080/1120009X.2022.2104294 | ISI #: | 000842550500001 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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