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Title: | Point scintillator dosimetry in ultra-high dose rate electron "FLASH" radiation therapy: A first characterization | Authors: | Vanreusel, Verdi Gasparini, Alessia Galante, Federica Mariani, Giulia Pacitti, Matteo Cociorb, Madalina Giammanco, Andrea RENIERS, Brigitte REULENS, Nathalie Shonde, Tunde Blessed Vallet, Hugo Vandenbroucke, Dirk Peeters , Marc Leblans, Paul Ma, Biwu Felici, Giuseppe Verellen, Dirk Nascimento, Luana de Freitas |
Issue Date: | 2022 | Publisher: | ELSEVIER SCI LTD | Source: | Physica Medica-European Journal of Medical Physics, 103 , p. 127 -137 | Abstract: | FLASH radiation therapy is a novel technique combining ultra-high dose rates (UHDR) with very short treatment times to strongly decrease normal tissue toxicity while preserving the anti-tumoral effect. However, the radiobiological mechanisms and exact conditions for obtaining the FLASH-effect are still under investigation. There are strong indications that parameters defining the beam structure, such as dose per pulse, instantaneous dose rate and pulse repetition frequency (PRF) are of importance. UHDR irradiations therefore come with dosimetric challenges, including both dose assessment and temporal ones. In this work, a first characterization of 6 real-time point scintillating dosimeters with 5 phosphors (Al2O3:C,Mg; Y2O3:Eu; Al2O3:C; (C38H34P2)MnBr4 and (C38H34P2)MnCl4, was performed in an UHDR pulsed electron beam. The dose rate independence of the calibration was tested by calibrating the detector at conventional and UHDR. Dose rate dependence was observed, however, further investigation, including intermediate dose rates, is needed. Linearity of the response with dose was tested by varying the number of pulses and a linearity with R-2 > 0.9989 was observed up to at least 200 Gy. Dose per pulse linearity was investigated by variation of the pulse length and SSD. All point scintillators showed saturation effects up to some extent and the instantaneous dose rate dependence was confirmed. A PRF dependence was observed for the Al2O3:C,Mg and Al2O3:C- based point scintillators. This was expected as the luminescence decay time of these materials exceeds the inter-pulse time. | Notes: | Vanreusel, V (corresponding author), SCK CEN, Res Dosimetr Applicat, Mol, Belgium.; Vanreusel, V (corresponding author), Univ Antwerp, CORE, Antwerp, Belgium.; Vanreusel, V (corresponding author), Iridium Netwerk, Antwerp, Belgium. verdi.vanreusel@sckcen.be |
Keywords: | FLASH-RT;Real-time dosimetry;Radioluminescence;Point scintillators | Document URI: | http://hdl.handle.net/1942/39006 | ISSN: | 1120-1797 | e-ISSN: | 1724-191X | DOI: | 10.1016/j.ejmp.2022.10.005 | ISI #: | 000880766300002 | Rights: | 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2023 |
Appears in Collections: | Research publications |
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Point scintillator dosimetry in ultra-high dose rate electron “FLASH” radiation therapy_ A first characterization.pdf Restricted Access | Published version | 2.45 MB | Adobe PDF | View/Open Request a copy |
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