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http://hdl.handle.net/1942/4032
Title: | Flexible surrogate marker evaluation from several randomized clinical trials with continuous endpoints, using R and SAS | Authors: | TILAHUN ESHETE, Abel Pryseley, Assam ALONSO ABAD, Ariel MOLENBERGHS, Geert |
Issue Date: | 2007 | Publisher: | ELSEVIER SCIENCE BV | Source: | COMPUTATIONAL STATISTICS & DATA ANALYSIS, 51(9). p. 4152-4163 | Abstract: | The evaluation of surrogate endpoints is thought to be first studied by Prentice, who presented a definition of a surrogate as well as a set of criteria. These criteria were later supplemented with the so-called proportion explained after notifying some drawbacks in Prentice's approach. Subsequently, the evaluation exercise was framed within a meta-analytic setting, thereby overcoming difficulties that necessarily surround evaluation efforts based on a single trial. The meta-analytic approach for continuous outcomes is briefly reviewed. Advantages and problems are highlighted by means of two case studies, one in schizophrenia and one in ophthalmology, and a simulation study. One of the critical issues for the broad adoption of methodology like the one presented here is the availability of flexible implementations in standard statistical software. Generically applicable SAS macros and R functions are developed and made available to the reader. (c) 2007 Elsevier B.V. All rights reserved. | Notes: | Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium.MOLENBERGHS, G, Hasselt Univ, Ctr Stat, Agoralaan 1, B-3590 Diepenbeek, Belgium.geert.molenberghs@uhasselt.be | Keywords: | adjusted association; hierarchical model; meta-analysis; proportion explained; random-effects model; relative effect; surrogate endpoint;adjusted association; hierarchical model; meta-analysis; proportion explained; random-effects model; relative effect; surrogate endpoint | Document URI: | http://hdl.handle.net/1942/4032 | ISSN: | 0167-9473 | e-ISSN: | 1872-7352 | DOI: | 10.1016/j.csda.2007.02.007 | ISI #: | 000246606000005 | Rights: | © 2007 Elsevier B.V. All rights reserved | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2008 |
Appears in Collections: | Research publications |
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