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Title: | Air pollution exposure and bone mineral density in young children: results from the ENVIRONAGE birth cohort | Authors: | BENTO FONSECA E SILVA, Ana Inês SLEURS, Hanne DOCKX, Yinthe RASKING, Leen WANG, Congrong PLUSQUIN, Michelle BIJNENS, Esmee NAWROT, Tim |
Issue Date: | 2023 | Publisher: | ELSEVIER IRELAND LTD | Source: | TOXICOLOGY LETTERS, 384 , p. S317 | Abstract: | Previous epidemiological studies have suggested that air pollution exposure has an adverse effect on bone health in older individuals. However , no studies on early life exposure to air pollution and childhood bone mineral density have been reported. Therefore, this study aims to investigate whether long-term exposure to air pollution is associated with a change in bone mineral density in young children. Within the ongoing prospective birth cohort ENVIRONAGE (Envi-ronmental Influence on Ageing in Early Life), a total of 478 children aged 4-6 were followed-up. Radial bone mineral density (m/s) was assessed using a quantitative ultrasound method. The residential air pollution exposure (μg/m 3) one year before the follow-up was estimated using a high-resolution spatial-temporal interpolation method. Multiple linear regression models were used after adjusting for relevant covariates and potential confounders. Radial bone mineral density was on average (SD) 3680.84 (112.39) m/s. An interquartile (IQR) increment in long-term exposure to PM 2.5 (2.54 μg/m 3) and PM 10 (3.65 μg/m 3) was associated with a decrease of 24.81 m/s (95% CI:-42.55% to-7.07%, p=0.006) and 26.24 m/s (95% CI:-41.95% to 10.54%, p=0.001) in bone mineral density, respectively. On the other hand, no significant associations were observed for long-term exposure to nitrogen dioxide and black carbon. These findings provide evidence that long-term exposure to particulate matter has a relevant effect on childhood bone mineral density. Moreover, this study reinforces the need for increased public health policies and awareness campaigns on air quality improvement with long-term implications on bone health. | Document URI: | http://hdl.handle.net/1942/41814 | ISSN: | 0378-4274 | e-ISSN: | 1879-3169 | ISI #: | 001065901700743 | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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