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http://hdl.handle.net/1942/45786| Title: | A nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer | Authors: | VOLDERS, Pieter-Jan Aftimos, Philippe Dedeurwaerdere, Franceska Martens, Geert Canon, Jean-Luc Beniuga, Gabriela Van Huysse, Jacques FROYEN, Guy De Pauw, Rebecca Prenen, Hans Lambin, Suzan Decoster, Lore Vaeyens, Freya Rottey, Sylvie Van Dam, Pieter-Jan Decoster, Lynn Rutten, Annemie Schreuer, Max Loontiens, Siebe van der Meulen, Joni MEBIS, Jeroen CUPPENS, Kristof Tejpar, Sabine Vanden Bempt, Isabelle De Greve, Jacques Schroeder, David van Marcke, Cedric van den Bulcke, Marc de Azambuja, Evandro Punie, Kevin MAES, Brigitte |
Issue Date: | 2025 | Publisher: | NATURE PORTFOLIO | Source: | Npj Precision Oncology, 9 (1) (Art N° 66) | Abstract: | The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) study assessed the feasibility of using comprehensive genomic profiling (CGP) in clinical decision-making for patients with advanced cancers. This multi-center study enrolled 872 patients from 12 Belgian hospitals. CGP was performed on tumor tissues using a standardized CGP panel (523 genes) across nine laboratories with success in 93% of patients and a median turnaround time of 29 days. Actionable genomic markers were identified in 81% of patients, substantially higher than the 21% using nationally reimbursed, small panels. A national molecular tumor board (nMTB) recommended treatments for 69% of patients, with 23% receiving matched therapies. Reasons for non-compliance were highly variable across clinical sites. Overall, BALLETT demonstrates the feasibility of implementing decentralized CGP and its potential to identify actionable targets in most patients with advanced cancers. BALLETT reinforces CGP's utility and emphasizes the importance of collaboration, standardization, and addressing implementation challenges. | Notes: | Maes, B (corresponding author), Jessa Hosp, Lab Mol Diagnost, Hasselt, Belgium.; Maes, B (corresponding author), Univ Hasselt, Fac Med & Life Sci, LCRC, Hasselt, Belgium. Brigitte.maes@jessazh.be |
Document URI: | http://hdl.handle.net/1942/45786 | e-ISSN: | 2397-768X | DOI: | 10.1038/s41698-025-00858-0 | ISI #: | 001441014500001 | Rights: | The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution |
| Appears in Collections: | Research publications |
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