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http://hdl.handle.net/1942/673
Title: | A perspective on surrogate endpoints in controlled clinical trials | Authors: | MOLENBERGHS, Geert BURZYKOWSKI, Tomasz ALONSO ABAD, Ariel BUYSE, Marc |
Issue Date: | 2004 | Publisher: | ARNOLD | Source: | Statistical Methods in Medical Research, 13(3). p. 177-206 | Abstract: | The last couple of decades have seen a large amount of activity in the area of surrogate marker and surrogate endpoint validation, both from a clinical and a statistical perspective. Prentice1 made a pivotal contribution in the context of a single trial. Subsequently, the framework he proposed has been discussed, criticized, and extended. An important class of extensions considers several rather than a single trial. Recently, a lot of work has been done in this so-called hierarchical or meta-analytic framework. In this paper, we review both the single trial and the hierarchical framework. A number of applications, scattered throughout the literature, are brought together. We outline the statistical issues involved in trying to validate surrogate endpoints. Clearly statistical evidence should only be seen as a component in a decision making process that also involves a number of clinical and biological considerations. | Document URI: | http://hdl.handle.net/1942/673 | ISSN: | 0962-2802 | e-ISSN: | 1477-0334 | DOI: | 10.1191/0962280204sm362ra | ISI #: | 000221873600001 | Rights: | (C) Arnold 2004 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2005 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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burt13.pdf | Published version | 581.29 kB | Adobe PDF | View/Open |
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