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http://hdl.handle.net/1942/8744
Title: | Evaluating time to cancer recurrence as a surrogate marker for survival from an information theory perspective | Authors: | ALONSO ABAD, Ariel MOLENBERGHS, Geert |
Issue Date: | 2008 | Publisher: | SAGE PUBLICATIONS LTD | Source: | STATISTICAL METHODS IN MEDICAL RESEARCH, 17(5). p. 497-504 | Abstract: | The last two decades have seen a lot of development in the area of surrogate marker validation. One of these approaches places the evaluation in a meta-analytic framework, leading to definitions in terms of trial- and individual-level association. A drawback of this methodology is that different settings have led to different measures at the individual level. Using information theory, Alonso et al. proposed a unified framework, leading to a new definition of surrogacy, which offers interpretational advantages and is applicable in a wide range of situations. In this work, we illustrate how this information-theoretic approach can be used to evaluate surrogacy when loth endpoints are of a time-to-event type. Two meta-analyses, in early and advanced colon cancer, respectively, are then used to evaluate the performance of time to cancer recurrence as a surrogate for overall survival. | Notes: | [Alonso, Ariel; Molenberghs, Geert] Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium. | Document URI: | http://hdl.handle.net/1942/8744 | ISSN: | 0962-2802 | e-ISSN: | 1477-0334 | DOI: | 10.1177/0962280207081851 | ISI #: | 000260216700005 | Rights: | © 2008 SAGE Publications | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2009 |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Evaluating time to cancer recurrence.pdf | Peer-reviewed author version | 88.69 kB | Adobe PDF | View/Open |
alonso2008.pdf Restricted Access | Published version | 105.77 kB | Adobe PDF | View/Open Request a copy |
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