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Title: | Contact patterns and their implied basic reproductive numbers: an illustration for varicella-zoster virus | Authors: | VAN EFFELTERRE, Thierry SHKEDY, Ziv AERTS, Marc MOLENBERGHS, Geert Van Damme, P. Beutels, P. |
Issue Date: | 2009 | Publisher: | CAMBRIDGE UNIV PRESS | Source: | EPIDEMIOLOGY AND INFECTION, 137(1). p. 48-57 | Abstract: | The WAIFW matrix (Who Acquires Infection From Whom) is a central parameter in modelling the spread of infectious diseases. The calculation of the basic reproductive number (R-0) depends on the assumptions made about the transmission within and between age groups through the structure of the WAIFW matrix and different structures might lead to different estimates for R-0 and hence different estimates for the minimal immunization coverage needed for the elimination of the infection in the population. In this paper, we estimate R-0 for varicella in Belgium. The force of infection is estimated from seroprevalence data using fractional polynomials and we show how the estimate of R-0 is heavily influenced by the structure of the WAIFW matrix. | Notes: | [Van Effelterre, T.; Shkedy, Z.; Aerts, M.; Molenberghs, G.] Hasselt Univ, Ctr Stat Biostat, B-3590 Diepenbeek, Belgium. [Van Damme, P.; Beutels, P.] Univ Antwerp, Ctr Evaluat Vaccinat, B-2020 Antwerp, Belgium. [Beutels, P.] Univ Sydney, Natl Ctr Immunizat Res & Surveillance, Sydney, NSW 2006, Australia. | Document URI: | http://hdl.handle.net/1942/9216 | ISSN: | 0950-2688 | e-ISSN: | 1469-4409 | DOI: | 10.1017/S0950268808000563 | ISI #: | 000262067800005 | Rights: | © 2008 Cambridge University Press | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
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