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http://hdl.handle.net/1942/9290
Title: | Evaluation of Biomarkers for Pharmacological Activity | Authors: | ALONSO ABAD, Ariel MOLENBERGHS, Geert RENARD, Didier Darstein, Christelle |
Issue Date: | 2009 | Publisher: | TAYLOR & FRANCIS INC | Source: | JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 19(2). p. 256-272 | Abstract: | In recent years the cost of drug development has increased the demands on efficiency in the selection of suitable drug candidates. Biomarkers for efficacy and safety could be a plausible strategy to improve this selection process. In the present work, we focus on the study and evaluation of different physiological variables as biomarkers for pharmacological activity. We proposed three different approaches using multivariate and univariate techniques. We note that even though one could argue that the multivariate procedure is more powerful than the other alternatives, the univariate methods also offer a great flexibility to answer interesting scientific questions. The three approaches were used to analyze a crossover study involving an opioid antagonist. | Notes: | [Alonso, Ariel; Molenberghs, Geert] Hasselt Univ, Ctr Stat, B-3590 Diepenbeek, Belgium. [Renard, Didier] Novartis Pharma AG, Exploratory Dev, Clin Informat Sci, Basel, Switzerland. [Darstein, Christelle] Lilly Corp Ctr, Lilly Serv SA, Program Phase Stat, Indianapolis, IN USA. | Keywords: | Biomarkers; Crossover; Optimization; Surrogate marker;biomarkers; crossover; optimization; surrogate marker | Document URI: | http://hdl.handle.net/1942/9290 | ISSN: | 1054-3406 | e-ISSN: | 1520-5711 | DOI: | 10.1080/10543400802622386 | ISI #: | 000263291400003 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2010 |
Appears in Collections: | Research publications |
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alonso2009.pdf Restricted Access | Published version | 513.14 kB | Adobe PDF | View/Open Request a copy |
GeertMolenberghs3.pdf | Peer-reviewed author version | 288.92 kB | Adobe PDF | View/Open |
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