Please use this identifier to cite or link to this item:
Title: Adjusting pairwise nonparametric equivalence hypothesis tests and confidence intervals for period effects in 3x3 crossover trials
Authors: DUCHATEAU, Luc 
Otoul, Christian
Issue Date: 2002
Source: Journal of Biopharmaceutical Statistics, 12(2). p. 149-160
Abstract: In pharmacokinetic and pharmacodynamic 3x3 crossover trials, average bioequivalence and noninferiority between treatments need to be only assessed pairwise in most cases. Due to the restricted number of subjects in such trials, normal distribution assumptions cannot be checked and frequently outliers are encountered, so that a nonparametric approach is more adequate. Therefore, to assess average bioequivalence or noninferiority, a new method is proposed to derive period adjusted nonparametric confidence intervals for pairwise treatment differences.
Keywords: 3x3 crossover trial; pairwise comparisons; equivalence hypotheses; noninferiority hypothesis; Hodges-Lehmann confidence interval
Document URI:
Category: A2
Type: Journal Contribution
Appears in Collections:Research publications

Show full item record

Page view(s)

checked on May 15, 2022

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.