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Title: | Interdisciplinary advances towards understanding and enhancing the therapeutic potential of stem cell-based therapies for ischaemic stroke | Authors: | GERVOIS, Pascal DILLEN, Yorg VANGANSEWINKEL, Tim HILKENS, Petra DRIESEN, Ronald MERCKX, Greet LO MONACO, Melissa RATAJCZAK, Jessica BRONCKAERS, Annelies LAMBRICHTS, Ivo WOLFS, Esther |
Issue Date: | 2017 | Publisher: | Springer International Publishing | Source: | Lapchak, Paul A.; Zhang, John H. (Ed.). Cellular and Molecular Approaches to Regeneration and Repair, Springer International Publishing, p. 21-45 | Series/Report: | Springer Series in Translational Stroke Research | Abstract: | Worldwide, stroke is the second single most common cause of death and is a major cause of permanent disability. Moreover, the highest incidence of these pathologies is observed in the elderly, increasing the socioeconomic burden in an aging population. Current available therapies lead to insufficient functional improvement or are not applicable to all patients. This stresses the urgent need for alternative strategies in treating stroke patients, for example cell-based therapies. These cells showed great preclinical potential although the underlying therapeutic mechanisms, preferential route of administration and most suitable stem cell-subtype are unknown. Mechanisms of action include neuroprotection, cell replacement, neurogenesis, immunomodulation and the promotion of both neuroplasticity and angiogenesis in damaged central nervous system regions. Moreover, stem cells have been genetically engineered to enhance their beneficial effects after transplantation. Additionally, noninvasive imaging can be used to provide detailed spatial and functional information on the donor cell fate and the response of the host microenvironment. This chapter provides an overview of recent advances in (bio-)medical research using or manipulating stem cell-based therapies for ischaemic stroke with a focus on their neuroprotective, neuroregenerative and immunomodulatory properties. Additionally, the use of noninvasive imaging to allow temporospatial evaluation of stem cell fate following transplantation in animal stroke models will be discussed. | Keywords: | stem cell; ischaemic stroke; noninvasive imaging; gene therapy; regenerative medicine; immunomodulation | Document URI: | http://hdl.handle.net/1942/25589 | ISBN: | 9783319666785 | DOI: | 10.1007/978-3-319-66679-2_2 | Rights: | © Springer International Publishing AG 2018 | Category: | B2 | Type: | Book Section | Validations: | vabb 2019 |
Appears in Collections: | Research publications |
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PGervois2017_Translational stroke research_Book Chapter.pdf Restricted Access | Published version | 397.31 kB | Adobe PDF | View/Open Request a copy |
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