Electrochemical sensor platform for MIP incorporated microfluidic paper-based analytical devices

Abstract

A biomimetic sensor platform capable of performing electrochemical measurements for the detection of molecules was developed by incorporating molecularly imprinted polymers (MIPs) into microfluidic paper-based analytical devices(µPADs). The usage of µPADs in combination with electrochemical measurements vastly improves several parameters compared to lab-sized electrochemical setups. Interdigitated electrodes were utilized, this way no top electrode is needed. The amplitude of the impedance was monitored and a complete impedance spectrum was measured continuously. The combination of low-cost, disposable paper-based microfluidics and electrochemical read-out, make an ideal point-of-care application.