Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/659
Title: | Validation of a longitudinally measured surrogate for a time-to-event endpoint | Authors: | RENARD, Didier GEYS, Helena MOLENBERGHS, Geert BURZYKOWSKI, Tomasz BUYSE, Marc VANGENEUGDEN, Tony BIJNENS, Luc |
Issue Date: | 2003 | Publisher: | CARFAX PUBLISHING | Source: | Journal of Applied Statistics, 30(2). p. 235-247 | Abstract: | The objective of this paper is to extend the surrogate endpoint validation methodology proposed by Buyse et al. (2000) to the case of a longitudinally measured surrogate marker when the endpoint of interest is time to some key clinical event. A joint model for longitudinal and event time data is required. To this end, the model formulation of Henderson et al. (2000) is adopted. The methodology is applied to a set of two randomized clinical trials in advanced prostate cancer to evaluate the usefulness of prostate-specific antigen (PSA) level as a surrogate for survival. | Document URI: | http://hdl.handle.net/1942/659 | ISSN: | 0266-4763 | e-ISSN: | 1360-0532 | DOI: | 10.1080/0266476022000023776 | ISI #: | 000180623500008 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2004 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
burt1.pdf | Published version | 341.67 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
20
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
23
checked on Apr 14, 2024
Page view(s)
40
checked on Sep 7, 2022
Download(s)
20
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.