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Title: | Design of a Lab-on-Chip Cartridge for the Optical Detection of Small Molecules Based on Dye-Displacement MIPs | Authors: | GOOSSENS, Juul VANDENRYT, Thijs Lowdon, Joseph W. W. VAN GRINSVEN, Bart EERSELS, Kasper DEFERME, Wim THOELEN, Ronald |
Issue Date: | 2023 | Publisher: | IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC | Source: | IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 72 (Art N° 9511209) | Abstract: | Molecular imprinted polymers (MIPs) are well known for their specific recognition of a wide variety of different analytes. However, the complex immobilization process of MIPs onto sensor electrodes poses a significant challenge. This research introduces a novel approach to enhance the application potential of MIPs by exploiting dye-displacement MIPs. These synthetic receptors can selectively release dye upon exposure to an aqueous target. A disposable and low-cost lab-on-chip cartridge is presented, enabling the MIPs to interact with the target solution for dye displacement. Furthermore, these cartridges are coupled to a portable optical sensor setup that can be used for screening samples in a user-friendly and fast manner. Characterization experiments demonstrate the capability of the spectrometer setup to identify different color dyes and intensities. Finally, a proof-of-application shows the use of our sensing setup for the indirect detection of 2-methoxphenidine (2-MXP) using dye-loaded MIPs, employing a dose-response characterization (4PL). Furthermore, as the dye displacement and sensing principle are universal, this setup holds promise for various other sensing applications, including food quality assessment, environmental testing, and pharmaceutical analysis. | Notes: | Goossens, J (corresponding author), Hasselt Univ, Inst Mat Res IMO, B-3590 Diepenbeek, Belgium.; Goossens, J (corresponding author), IMECvzw, Div IMOMEC, B-3590 Diepenbeek, Belgium. juul.goossens@uhasselt.be; thijs.vandenryt@uhasselt.be; joe.lowdon@maastrichtuniversity.nl; bart.vangrinsven@maastrichtuniversity.nl; kasper.eersels@maastrichtuniversity.nl; wim.deferme@uhasselt.be; ronald.thoelen@uhasselt.be |
Keywords: | Optical variables measurement;Optical sensors;Lab-on-a-chip;Fluid flow measurement;Optical pumping;Light emitting diodes;Adaptive optics;Dye-displacement molecular imprinted polymer (MIP);integrated lab-on-chip cartridge;portable spectrometer | Document URI: | http://hdl.handle.net/1942/40829 | ISSN: | 0018-9456 | e-ISSN: | 1557-9662 | DOI: | 10.1109/TIM.2023.3301040 | ISI #: | 001049981700008 | Rights: | 2023 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Design of a Lab-on-Chip Cartridge for the Optical Detection of Small Molecules Based on Dye-Displacement MIPs.pdf Restricted Access | Published version | 3.36 MB | Adobe PDF | View/Open Request a copy |
Article_design_of_lab-on-chip (2).pdf Until 2025-08-03 | Peer-reviewed author version | 8.58 MB | Adobe PDF | View/Open Request a copy |
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