Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/463
Title: | Challenges in the methodology for the validation of surrogate endpoints in randomized trials | Authors: | MOLENBERGHS, Geert BUYSE, Marc GEYS, Helena RENARD, Didier BURZYKOWSKI, Tomasz |
Issue Date: | 2002 | Source: | Stasinopoulos, Mikis & Touloumi, Giota (Ed.) Proceedings of the 17th International Workshop on Statistical Modelling. p. 491-498. | Abstract: | The validation of surrogate endpoints has been studied by Prentice (1989). He presented a definition as well as a set of criteria that are equivalent if the surrogate and true endpoints are binary. Freedman (1992) supplemented these criteria with the so-called proportion explained. Buyse and Molenberghs (1998) proposed to replace the proportion explained by two quantities: (1) the relative effect linking the effect of treatment on both endpoints and (2) the adjusted association, an individual-level measure of agreement between both endpoints. In this paper, we argue that a meta-analytic approach should be adopted because it overcomes difficulties which necessarily surround validation efforts based on a single trial. | Keywords: | adjusted Assocation; meta-analysis; proportion explained; random effects model; relative effect; surrogate endpoint; validation | Document URI: | http://hdl.handle.net/1942/463 | Link to publication/dataset: | http://www.statmod.org/files/proceedings/iwsm2002_proceedings.pdf | Category: | C2 | Type: | Proceedings Paper |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
iwsm2002_proceedings-500-507.pdf | Published version | 410.13 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.